文献类型：期刊文献

英文题名：Learn from microbial intelligence for avermectins overproduction

作者：Gao, Qiang[2];Tan, Gao-Yi[1];Xia, Xuekui[3];Zhang, Lixin[1,3,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Tianjin Univ Sci & Technol, Coll Biotechnol, Minist Educ, Key Lab Ind Fermentat Microbiol, Tianjin 300457, Peoples R China;[3]Shandong Acad Sci, Biol Inst, Key Biosensor Lab Shandong Prov, Jinan 250014, Shandong, Peoples R China;[4]Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266061, Peoples R China

年份：2017

卷号：48

起止页码：251

外文期刊名：CURRENT OPINION IN BIOTECHNOLOGY

收录：;EI(收录号：20174304291535);WOS:【SCI-EXPANDED(收录号:WOS:000418313200033)】；

基金：We dedicate this paper to and in memory of our beloved friend and colleague, Prof. Keqian Yang, who devoted his life to Streptomyces physiology, antibiotics biosynthesis and regulations. The authors would like to thank Changming Zhao, Chunbo Lou, Yong Tao, Yihua Chen, Huarong Tan, Minyong Li, Shi Chen and Weishan Wang for helpful discussions. We gratefully acknowledge the financial support in part from the 973 Program of China (grant number 2013CB734000), the National Science Foundation of China (grant numbers 31370075, 31320103911, 31430002, 31511130136), and Shandong Taishan Scholar Program of China for Lixin Zhang.

语种：英文

摘要：Microbial strains are amazingly clever by homeostasis of their own survival and optimization for the overproduction of a desired phenotype, for example drugable secondary metabolites through coordination of key genes overexpression and media optimizations. Besides their pesticide activities, avermectins(AVMs) are identified as potent antibiotic agents for a wide range of drug-resistant pathogens by a high throughput synergy screening strategy. To rewire the genetic circuitry controlling low yields, we summarized the work on balancing the biological chassis with functional parts, and optimized their dynamical process, as well as predicted favorable effective overproduction of AVMs by 5Ms strategy. AVMs are exclusively made in China now and intelligences learned from the success of AVMs will help transform microbes into a true power-house of innovation.