文献类型：期刊文献

英文题名：An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

作者：Li Hui[1];Yu JinLong[1];Cao Song[1];Shen Li[1];Wu MingXi[1];Cheng JianHang[1];Qian XuHong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Ctr Fluorine Chem Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2010

卷号：53

期号：7

起止页码：1509

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20103313156021);WOS:【SCI-EXPANDED(收录号:WOS:000280481500010)】；

基金：This work was supported by the National Basic Research Program of China (2010CB126101), Shanghai Foundation of Science and Technology (09391911800), the National High Technology Research and Development Program of China (2006AA10A201), and the Shanghai Leading Academic Discipline Project (B507).

语种：英文

外文关键词：three-component; difluoromethyl; 1,4-dihydropyridines; ethyl difluoroacetoacetate

摘要：The difluoromethyl-containing Hantzsch 1,4-dihydropyridines were synthesized in good yields by a one-pot cyclocondensation of ethyl difluoroacetoacetate (EDFAA), a variety of aromatic aldehydes and ammonium acetate under solvent and catalyst free conditions. The comparison of reaction conditions and products was made among the different 1,3-carbonyl substrates (ethyl acetoacetate, ethyl difluoroacetoacetate and ethyl trifluoroacetoacetate) for the Hantzsch reaction.