文献类型：期刊文献

英文题名：Multifunctional Fe3O4@SiO2-CDs magnetic fluorescent nanoparticles as effective carrier of gambogic acid for inhibiting VX2 tumor cells

作者：Guan, Yuxia[1];Yang, Yuxiang[1,2];Wang, Xinxin[1];Yuan, Hongming[3];Yang, Yuxing[4];Li, Na[1];Ni, Chaoying[2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA;[3]Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China;[4]Changzhou Tumor Hosp, Changzhou 213000, Peoples R China

年份：2021

卷号：327

外文期刊名：JOURNAL OF MOLECULAR LIQUIDS

收录：;EI(收录号：20204809546491);WOS:【SCI-EXPANDED(收录号:WOS:000637200400001)】；

基金：This work was supported by the National Natural Science Foundation of China (20577010, 20971043), and the Open Project Program of State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University.

语种：英文

外文关键词：Magnetic nanoparticles; Fluorescent carbon quantum dots; Magnetic targeting; Tumor therapy; Drug sustained release

摘要：This paper reports a dual-functional platform that can be used for synergistic therapy, including drug release and magnetic targeting. The platformis realized through an amide reaction between high-fluorescence carbon quantumdots (CD) prepared bymicrowave method and amino-functional Fe3O4@SiO2 with high saturation magnetic strength and a core-shell structure to obtain multifunctional magnetic fluorescent nanocomposite particles Fe3O4@SiO2-CDs. The structure, drug release behavior, cytotoxicity, fluorescence and distribution in vivo of Fe3O4@SiO2-CDs nanoparticleswere studied. The results showthat the Fe3O4@SiO2-CDs with a dynamic diameter of about 155.0 nm and a magnetic saturation intensity of 31.2 emu/g has a higher loading of gambogic acid (GA), and is more conducive to drug release in an environment of pH= 5.7. In addition, Fe3O4@SiO2-CDs has low cytotoxicity and can enter VX2 cells. However, GA-loaded Fe3O4@SiO2-CDs has an inhibitory effect on VX2 cells, and the cell survival rate is less than 20% at a concentration of 100 mu g/mL. Magnetic targeting experiments show that bifunctional magnetic nanoparticles have an outstanding magnetic targeting effect on tumors. (C) 2020 Elsevier B.V. All rights reserved.