文献类型：期刊文献

中文题名：丹参酮-预胶化淀粉共研磨混合物的研究

英文题名：Study on ground mixture of tanshinone pregeletiniged starch

作者：储茂泉[1];古宏晨[2];刘国杰[1]

机构：[1]华东理工大学化学与制药学院,上海200237;[2]教育部超细材料制备与应用重点实验室

年份：2001

卷号：18

期号：5

起止页码：359

中文期刊名：中国现代应用药学

外文期刊名：Chinese Journal of Modern Applied Pharmacy

收录：CSTPCD;;北大核心:【北大核心2000】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：丹参酮;预胶化淀粉;共研磨混合物;溶出度

外文关键词：Tanshinone, Pregeletiniged Starch, ground mixture, dissolution

摘要：目的 :提高难溶性药物丹参酮 ( Tanshinone TAN )的溶出度。方法 :将 TAN与预胶化淀粉 ( Pregeletiniged Starch PGS)共研磨制备成共研磨混合物 ,测定了 TAN原料药和共研磨混合物的溶出度 ,通过扫描电镜分析了丹参酮的存在状态。结果 :共研磨混合物的溶出度较 TAN原料药有显著提高 ,共研磨 3 h的共研磨混合物中 ,TAN以无定形态或超微颗粒附着于载休表面。结论 :将 TAN与 PGS共研磨能有效地改善 TAN的溶出度 ,且方法简便。
OBJECTIVE: To improve the dissolution rate of a poorly water soluble drug, tanshinone (TAN).METHOD:Ground mixture of TAN with pregeletiniged starch (PGS) were prepared by co grinding in a ball mill. The dissolution rate of TAN and ground mixtures were detected. Scanning electron microscope was used to investigate the study forms. RESULTS: The dissolution rate of TAN from the ground mixtures was significantly greater than that from the intact TAN powder. The size of the crystals of TAN in ground mixture was greatly reduced, and TAN was mainly in amorphous state or ultrafine particles forms after being co ground with PGS for 3h.CONCLUSION:The dissolution rate of TAN can be improved by co grinding with PGS, and the method is simple.