文献类型：期刊文献

英文题名：A multifunctional nanoplatform delivering carbon monoxide and a cysteine protease inhibitor to mitochondria under NIR light shows enhanced synergistic anticancer efficacy

作者：Tang, Qi[1];Liu, Jing[1];Wang, Cheng-Bin[2,3];An, Lu[2,3];Zhang, Hai-Lin[1];Wang, Yi[1];Ren, Bing[1];Yang, Shi-Ping[2,3];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China;[3]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2022

卷号：14

期号：25

起止页码：9097

外文期刊名：NANOSCALE

收录：;EI(收录号：20222612280195);WOS:【SCI-EXPANDED(收录号:WOS:000812706300001)】；

基金：This study was financially supported by the National Nature Science Foundation of China (No. 21571062 to J. G. L.), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to J. G. L., and the Fundamental Research Funds for the Central Universities (No. 222201717003). All animal experiments were conducted in strict accordance with the protocol of the institutional Animal Protection and Animal Use Committee and approved by the Animal Ethics Committee of Shanghai Normal University.

语种：英文

外文关键词：Amino acids - Biocompatibility - Cancer cells - Chemotherapy - Diseases - Doping (additives) - Infrared devices - Mammals - Mitochondria - Photodynamic therapy - Semiconductor quantum dots

摘要：Photoactivated chemotherapy has attracted widespread attention due to its ability to circumvent the shortcomings of hypoxia in tumor tissues compared with traditional photodynamic therapy. In this work, novel multifunctional nanoplatform (1), Ru-inhibitor@TPPMnCO@N-GQDs, was designed and prepared, which was capable of mitochondria-targeted co-delivery of the cysteine protease inhibitor and carbon monoxide (CO) stimulated with an 808 nm near infrared (NIR) laser. Nanoplatform (1) was prepared by covalent attachment of a mitochondria-targeted CO donor (TPPMnCO) and a Ru(ii)-caged cysteine protease inhibitor (Ru-inhibitor) on the surface of fluorescent N-doped graphene quantum dots (N-GQDs). Nanoplatform (1) preferentially accumulated in the mitochondria of cancer cells and instantly delivered CO and the cysteine protease inhibitor upon 808 nm NIR light irradiation, thus damaging mitochondria and leading to significant in vitro and in vivo anticancer efficacy. In addition, nanoplatform (1) has good biocompatibility and did not exert any toxic side effects on mice during the period of treatment. The targeted subcellular mitochondrial co-delivery of CO and the cysteine protease inhibitor may provide new insights into CO and enzyme inhibitor combined therapies for cancer treatment.