文献类型：期刊文献

中文题名：连二亚硫酸钠引发的手性2-取代-4-戊烯酸的氟烷基化反应研究

英文题名：Fluoroalkylation of Chiral Enoic Acids Initiated by Sodium Dithionite

作者：杨雪艳[1];吕铁梅[1];朱胜杰[1];吴范宏[2,3]

机构：[1]华东理工大学化学与分子工程学院,上海200237;[2]上海应用技术学院化学与环境工程学院,上海200235;[3]中国科学院上海有机化学研究所有机氟化学重点实验室,上海200032

年份：2011

卷号：69

期号：7

起止页码：815

中文期刊名：化学学报

外文期刊名：Acta Chimica Sinica

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000290191600010)】；北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：手性烯酸;氟烷基化;连二亚硫酸钠;手性含氟内酯

外文关键词：γ-butyrolactone chiral enoic acid; fluoroalkylation; sodium dithionite; chiral fluorine-containing

摘要：研究了手性4-戊烯酸衍生物的氟烷基化反应.以连二亚硫酸钠为引发剂,在碱作用下,乙腈水溶液中手性4-戊烯酸与含氟碘代烷一锅法反应得到手性含氟γ-丁内酯.其结构经核磁共振、高分辨质谱、红外光谱确定.其绝对构型经单晶衍射确定.
The fluoroalkylation reaction of chiral 4-pentenoic acids with RFI was investigated. In aqeous acetonitrile, chiral 4-pentenoic acids reacted with fluoroalkyl iodide initiated by sodium dithitionite in the presence of base to afford chiral fluorine-containing y-butyrolactones. The structures of the compounds were comfirmed by NMR, IR, and HRMS techniques. The configurations were ascertained by X-ray single crystal diffraction.