文献类型：期刊文献

英文题名：In vitro degradability, bioactivity and primary cell responses to bone cements containing mesoporous magnesium-calcium silicate and calcium sulfate for bone regeneration

作者：Ding, Yueting[1];Tang, Songchao[1];Yu, Baoqing[2];Yan, Yonggang[3];Li, Hong[3];Wei, Jie[1];Su, Jiacan[2]

机构：[1]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed, Shanghai 200433, Peoples R China;[3]Sichuan Univ, Coll Phys Sci & Technol, Chengdu 610041, Peoples R China

年份：2015

卷号：12

期号：111

外文期刊名：JOURNAL OF THE ROYAL SOCIETY INTERFACE

收录：;EI(收录号：20154501497203);WOS:【SCI-EXPANDED(收录号:WOS:000363487600030)】；

基金：This study was supported by grants from the National Natural Science Foundation of China (51173041, 31271031), the National Science and Technology Support Plan Projects (no. 2012BAD32B01), the International Cooperation Project of the Ministry of Science and Technology of China (2013DFB50280), the Major International Joint Research Project between China and Korea (81461148033, 31311140253) and the Key Medical Program of Science and Technology Development of Shanghai (no. 12441902802).

语种：英文

外文关键词：mesoporous magnesium-calcium silicate; calcium sulfate; bone cement; degradability; cytocompatibility

摘要：Mesoporous calcium sulfate-based bone cements (m-CSBC) were prepared by introducing mesoporous magnesium-calcium silicate (m-MCS) with specific surface area (410.9 m(2) g(-1)) and pore volume (0.8 cm(3) g(-1)) into calcium sulfate hemihydrate (CSH). The setting time of the m-CSBC was longer with the increase of m-MCS content while compressive strength decreased. The degradation ratio of m-CSBC increased from 48.6 w% to 63.5 w% with an increase of m-MCS content after soaking in Tris-HCl solution for 84 days. Moreover, the m-CSBC containing m-MCS showed the ability to neutralize the acidic degradation products of calcium sulfate and prevent the pH from dropping. The apatite could be induced on m-CSBC surfaces after soaking in SBF for 7 days, indicating good bioactivity. The effects of the m-CSBC on vitamin D-3 sustained release behaviours were investigated. It was found that the cumulative release ratio of vitamin D-3 from the m-CSBC significantly increased with the increase of m-MCS content after soaking in PBS (pH = 7.4) for 25 days. The m-CSBC markedly improved the cell-positive responses, including the attachment, proliferation and differentiation of MC3T3-E1 cells, suggesting good cytocompatibility. Briefly, m-CSBC with good bioactivity, degradability and cytocompatibility might be an excellent biocement for bone regeneration.