文献类型：期刊文献

英文题名：Asymmetric organocatalytic Michael/α-alkylation reaction of α,β-unsaturated aldehyde with chloroacetophenone

作者：Li, Wenjun[1];Li, Xin[1];Ye, Tingting[1];Wu, Wenbin[1];Liang, Xinmiao[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

年份：2011

卷号：52

期号：21

起止页码：2715

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000290602100025)，CCR-EXPANDED(收录号:WOS:000290602100025)】；

基金：We thank Innovation Program of Shanghai Municipal Education Commission (11ZZ56), National Natural Science Foundation of China (20902018) and Shanghai Pujiang Program (08PJ1403300) for financial support.

语种：英文

外文关键词：Asymmetric catalysis; alpha,beta-Unsaturated aldehyde; Tandem reaction; Organocatalysis; Enantioselective

摘要：Asymmetric organocatalytic Michael/alpha-alkylation reactions of alpha,beta-unsaturated aldehydes with chloro-acetophenones have been developed. The biologically useful cyclopropane motifs were synthesized with high yields and up to >99% ee, >30:1 dr through Jorgensen-Hayashi catalyst under mild conditions. (C) 2011 Elsevier Ltd. All rights reserved.