文献类型：期刊文献

英文题名：LiHMDS-Promoted Palladium or Iron-Catalyzed ipso-Defluoroborylation of Aryl Fluorides

作者：Zhao, Xianghu[1];Wu, Mingsheng[1];Liu, Yisen[1];Cao, Song[1]

机构：[1]ECUST, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2018

卷号：20

期号：18

起止页码：5564

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000445711500009)，CCR-EXPANDED(收录号:WOS:000445711500009)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grant Nos. 21472043 and 21272070).

语种：英文

摘要：A novel and efficient method for the synthesis of arylboronic acid pinacol esters via a palladium- or iron-catalyzed cross-coupling reaction of aryl fluorides with bis(pinacolato)diboron (B(2)pin(2)) in the presence of LiHMDS was developed. The Pd-catalyzed defluoroborylation of fluoroarenes is compatible with a variety of functional groups such as primary and secondary amine, ketone, trifluoromethyl, alkoxy, and boryl. Remarkably, no external ligand is required for enhanced conversion efficiency.