文献类型：期刊文献

英文题名：Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process

作者：Heo, Su-Jin[1,2];Kim, Seung-Eon[2];Wei, Jie[1,3,4];Hyun, Yong-Taek[2];Yun, Hui-Suk[2];Kim, Dong-Hwa[1];Shin, Ji Won[1];Shin, Jung-Woog[1]

机构：[1]Inje Univ, Dept Biomed Engn, Project Team 1, Team BK21, Gimhae 621749, Gyeongnam, South Korea;[2]Korea Inst Mat Sci, Dept Future Technol, Chang Won 641831, Gyeongnam, South Korea;[3]Taesan Solut Ltd, R&D Dept, Seoul 135080, South Korea;[4]E China Univ Sci & Technol, Inst Biomat, Shanghai 200237, Peoples R China

年份：2009

卷号：89A

期号：1

起止页码：108

外文期刊名：JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

收录：;EI(收录号：20091211969595);WOS:【SCI-EXPANDED(收录号:WOS:000263981300010)】；

基金：Contract grant sponsor: Korea Institute of Materials Science

语种：英文

外文关键词：hydroxyapatite; nano- and microsized; poly (epsilon-caprolactone); rapid-prototyping technique; bone tissue engineering scaffold

摘要：Novel three-dimensional scaffolds consisting of nano- and microsized hydroxyapatite (HA)/poly(epsilon-caprolactone) (PCL) composite were fabricated using a modified rapid -prototyping (RP) technique for bone tissue engineering applications. The size of the nano-HA ranged from 20 to 90 nm, whereas that of the micro-HA ranged from 20 to 80 pm. The scaffold macropores were well interconnected, with a porosity of 72-73% and a pore size of 500 pm. The compressive modulus of the nano-HA/PCL and micro-HA/PCL scaffolds was 3.187 +/- 0.06 and 1.345 +/- 0.05 MPa, respectively. The higher modulus of the nano-HA/PCL composite (n-HPC) was to be likely caused by a dispersion strengthening effect. The attachment and proliferation of MG-63 cells on n-HPC were better than that on the micro-HA/PCL composite (m-HPC) scaffold. The n-HPC was more hydrophilic than the rn-HPC because of the greater surface area of HA exposed to the scaffold surface. This may give rise to better cell attachment and proliferation. Bioactive n-HA/PCL composite scaffold prepared using a modified RP technique has a potential application in bone tissue engineering. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 108-116, 2009