文献类型：期刊文献

中文题名：红霉素在丙酮-水系统中的溶解度

英文题名：Solubility of erythromycin in acetone water solution

作者：黄阿根[1];邬行彦[1]

机构：[1]华东理工大学生化工程系,上海200237

年份：1999

卷号：24

期号：6

起止页码：415

中文期刊名：中国抗生素杂志

外文期刊名：Chinese Journal of Antibiotics

收录：CSTPCD;;Scopus;北大核心:【北大核心1996】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：红霉素;丙酮;水溶液;溶解度;结晶

外文关键词：Erythromycin; Aqueous acetone solution; Solubility; Crystallization

摘要：测定了红霉素在不同温度下丙酮－ 水系统中的溶解度。当丙酮含量低时，呈反溶解度；丙酮含量高时，呈正溶解度，其临界点在丙酮浓度为２６％ （ｖ／ｖ）左右。考虑到生产实际情况，还测定了含０．１ｍ ｏｌ／Ｌ乳酸并以氨水调ｐＨ１０时，丙酮－ 水系统中的溶解度，发现溶解度要增大很多。还提出了选择最适结晶条件的若干建议。
The solubility of erythromycin in acetone water system at various temperatures has been determined. When acetone concentration is low, it exhibits the reverse solubility with respect to temperature, whereas at higher concentration it exhibits the normal solubility. The critical point was found to be at 26% (v/v) of acetone. In order to simulate the practical conditions, the solubilty in the system containing 0.1mol/L lactic acid with pH adjusted to 10.0 with ammonia water has also been determined, showing a substantially higher value. Some practical points for choosing the optimum conditions of crystallization were proposed.