文献类型：期刊文献

英文题名：Intrinsic sodium currents and excitatory synaptic transmission influence spontaneous firing in up and down activities

作者：Wang, Yihong[1];Xu, Xuying[1];Wang, Rubin[1]

机构：[1]East China Univ Sci & Technol, Inst Cognit Neurodynam, 130 Meilong Rd, Shanghai, Peoples R China

年份：2018

卷号：98

起止页码：42

外文期刊名：NEURAL NETWORKS

收录：;EI(收录号：20174804453929);WOS:【SCI-EXPANDED(收录号:WOS:000424796500004)】；

基金：This work is supported by the National Natural Science Foundation of China (Nos. 11232005 and 11702096) and the Fundamental Research Funds for the Central Universities (No. 222201714020).

语种：英文

外文关键词：Up and down states; Spontaneous firing; Intrinsic sodium dynamics; Excitation block

摘要：Periodic up and down transitions of membrane potentials are considered to be a significant spontaneous activity. These kinds of oscillations always accompany with some spontaneous firing in up state. Our previous theoretical studies mainly looked at the subthreshold up and down transitions and characteristics of up and down dynamics. In this paper, we focus on suprathreshold spontaneous firing of up and down transitions based on improved network model and its stimulations. The simulated results indicate that fast sodium current is critical to the generation of spontaneous neural firing. While persistent sodium current plays a part in spontaneous fluctuation. Both intrinsic fast and persistent sodium dynamics influence spontaneous firing rate and synchronous activity in up and down behavior. Meanwhile, blocking excitatory synaptic transmission decreases neural firing and reveals spontaneous firing. These simulated results are basically in accordance with experimental results. Through the observation and analysis of the findings, we prove the validity of the model so we can further adopt this model to study other properties and characteristics of the network, laying the foundation for further work on cortex activity. (C) 2017 Elsevier Ltd. All rights reserved.