文献类型：期刊文献

英文题名：Mechanical metal activation for Ni-catalyzed, Mn-mediated cross-electrophile coupling between aryl and alkyl bromides

作者：Wu, Sisi[1];Shi, Weijia[1];Zou, Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai, Peoples R China

年份：2021

卷号：45

期号：25

起止页码：11269

外文期刊名：NEW JOURNAL OF CHEMISTRY

收录：;EI(收录号：20212710577908);WOS:【SCI-EXPANDED(收录号:WOS:000659551000001)】；

基金：We are grateful for the financial support provided by the National Natural Science Foundation of China (21472041).

语种：英文

外文关键词：Nickel - Catalysis

摘要：Liquid-assisted grinding has been successfully applied to eliminate the requirements of chemical activators and anhydrous solvents in nickel-catalyzed, manganese-mediated cross-electrophile coupling between aryl and alkyl bromides. In addition to the traditional reaction parameters, mechanical ones, e.g. the rotational speed of mill, the filling degree of jar and ball size, have been found to affect the catalytic efficiency remarkably, implying the involvement of the regeneration of nickel(0) species in the rate-determining steps. A combined evaluation of the reaction and mechanical parameters led to an optimal condition under which a variety of n-alky aromatics with various functional groups could be readily obtained in good yields with a 1 mol% catalyst loading. The practical application of liquid-assisted grinding-enabled aryl/alkyl cross-electrophile coupling has been demonstrated in the gram-scale synthesis of 6-methoxytetralone.