文献类型：期刊文献

英文题名：Asymmetric vinylogous Michael reaction of α,β-unsaturated ketones with γ-butenolide under multifunctional catalysis

作者：Huang, Huicai[1];Yu, Feng[1];Jin, Zhichao[1];Li, Wenjun[1];Wu, Wenbin[1];Liang, Xinmiao[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China

年份：2010

卷号：46

期号：32

起止页码：5957

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000280658300035)，CCR-EXPANDED(收录号:WOS:000280658300035)】；

基金：We thank the Shanghai Pujiang Program (08PJ1403300), National Natural Science Foundation of China (20902018), the Fundamental Research Funds for the Central Universities and 111 project (B07023) for financial support.

语种：英文

摘要：A general and direct organocatalytic asymmetric vinylogous Michael reaction of c-butenolide with alpha,beta-unsaturated ketones was investigated with a multifunctional primary amine salt as catalyst. The reaction enables straightforward access toward synthetically versatile c-substituted butenolides from simple 2(5H)-furanone with satisfactory yields, diastereo- and enantioselectivities (up to 30 : 1 dr and 95-99% ee).