文献类型：期刊文献

中文题名：Facile fabrication of antioxidative and antibacterial hydrogel films to accelerate infected diabetic wound healing

作者：Haodong Zhang[1];Qian Liang[2];Yanxiu Ji[2];Qi Chen[1,2];Weinan Jiang[3];Donghui Zhang[1];Yueming Wu[1,2];Liangmin Yu[5,6];Wei Chen[7,8,9,10];Runhui Liu[1,2,3,4]

机构：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,200237,China;[2]Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Key Laboratory for Ultrafine Materials of Ministry of Education,Frontiers Science Center for Materiobiology and Dynamic Chemistry,Engineering Research Center for Biomedical Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;[3]Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Sciences,Suzhou,215163,China;[4]State Key Laboratory of Molecular Engineering of Polymers,Fudan University,Shanghai 200438,China;[5]Key Laboratory of Marine Chemistry Theory and Technology,Ministry of Education,Ocean University of China,Qingdao,266100,China;[6]Qingdao Collaborative Innovation Center of Marine Science and Technology,Ocean University of China,Qingdao,266100,China;[7]Department of Orthopedic Surgery,Hebei Medical University Third Hospital,Shijiazhuang,Hebei,China;[8]Engineering Research Center of Orthopedic Minimally invasive Intelligent Equipment,Ministry of Education,Shijiazhuang,Hebei,China;[9]NHC Key Laboratory of Intelligent Orthopedic Equipment,Shijiazhuang,Hebei,China;[10]Key Laboratory of Biomechanics of Hebei Province,Shijiazhuang,Hebei,China

年份：2025

卷号：53

期号：11

起止页码：386

中文期刊名：Bioactive Materials

外文期刊名：生物活性材料(英文)

基金：supported by National Key R&D Program of China(2024YFC2418700);the National Natural Science Foundation of China(No.T2325010);Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission);the Fundamental Research Funds for the Central Universities(Nos.JKVD1241029 and JKD01241701).

语种：英文

中文关键词：Antioxidative;Antibacterial;Hydrogel films;Infected diabetic wound healing;Wound dressing

摘要：Diabetic wounds are accompanied with hemorrhage,excessive reactive oxygen species accumulation,microbial infection,and poor exudate management.Current dressings are insufficient to modulate the complex pathophysiological microenvironment of infected diabetic wounds.Here,we develop a facile-fabricated hydrogel film with potent antibacterial and antioxidative properties to significantly accelerate infected diabetic wounds healing.The hydrogel film demonstrates potent antibacterial efficacy against methicillin-resistant Staphylococcus aureus and Escherichia coli,efficient scavenging of the extra-and intracellular reactive oxygen species,and enhanced fibroblast migration.In the methicillin-resistant Staphylococcus aureus infected diabetic wounds model,the hydrogel film treatment leads to reduced methicillin-resistant Staphylococcus aureus load,eliminated exudate accumulation,and significantly accelerated wound healing.In addition,the hydrogel film achieves rapid hemostasis by effective wound adhesion and fluid absorption.Collectively,this study provides a promising therapeutic option to promote infected diabetic wounds healing and management.