文献类型：期刊文献

英文题名：Efficient Synthesis of Chiral Indolines using an Imine Reductase from Paenibacillus lactis

作者：Li, Hao[1];Luan, Zheng-Jiao[1];Zheng, Gao-Wei[1];Xu, Jian-He[1]

机构：[1]E China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomanufacture, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2015

卷号：357

期号：8

起止页码：1692

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000355235700008)，CCR-EXPANDED(收录号:WOS:000355235700008)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 31200050 & 21472045), Ministry of Science and Technology, P. R. China (Nos. 2011CB710800 & 2012AA022201D) and the Fundamental Research Funds for the Central Universities (22A201514043). We also thank Prof. Ping Tian (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences) for his helpful discussions.

语种：英文

外文关键词：asymmetric hydrogenation; biocatalysis; chiral indolines; imine reductase; 3H-indoles

摘要：An enzymatic process for the efficient asymmetric reduction of 3H-indoles as well as 3H-indole iodides was developed for the first time. Using a new imine reductase identified from Paenibacillus lactis (PlSIR), various chiral indolines were facilely synthesized in good yields and excellent enantiopurities (up to > 99% ee) under mild reaction conditions.