文献类型：期刊文献

英文题名：Magnolol, a Neolignan-like Drug, Inhibits Porcine Epidemic Diarrhea Virus Replication in Cultured Cells

作者：Wang, Xiaoting[1];Chen, Bingqing[2];Yu, Ruisong[2];Si, Fusheng[2];Xie, Chunfang[2];Li, Zhen[2];Dong, Shijuan[2];Zhang, Daojing[1]

机构：[1]East China Univ Sci & Technol ECUST, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Acad Agr Sci SAAS, Inst Anim Husb & Vet Sci, Shanghai Engn Res Ctr Breeding Pig, Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China

年份：2023

卷号：12

期号：2

外文期刊名：PATHOGENS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000941003500001)】；

语种：英文

外文关键词：porcine epidemic diarrhea virus (PEDV); magnolol; antiviral effect; in vitro

摘要：Porcine epidemic diarrhea virus (PEDV) is a destructive pathogen that continues to adversely affect the swine industry worldwide due to a current lack of vaccines and drugs capable of effective disease control. In the present study, the neolignan-like drug, magnolol (MAG), was tested for its ability to inhibit a Vero-cell adapted PEDV strain DR13(att). Our data revealed that MAG exhibited anti-PEDV activity in vitro, with IC50 and CC50 values of 28.21 mu M and 57.28 mu M, respectively. MAG was an efficient inhibitor of viral replication, and repression of viral proliferation was strongest when the host cells were exposed to MAG and the virus at the same time. Although our data indicate that MAG has the potential to be a useful PEDV control agent, in vivo testing of the drug, using animal hosts, is required.