文献类型：期刊文献

英文题名：Iodine-catalyzed C3-formylation of indoles using hexamethylenetetramine and air

作者：Wang, Qing-Dong[1,2];Yang, Jin-Ming[2];Fang, Dong[2];Ren, Jiangmeng[1];Zeng, Bu-Bing[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Yancheng Teachers Univ, Sch Pharm, Yancheng 224051, Jiangsu, Peoples R China

年份：2017

卷号：58

期号：30

起止页码：2877

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000405973600001)，CCR-EXPANDED(收录号:WOS:000405973600001)】；

基金：We thank the National High Technology Research and Development Program of China (2007AA02Z301), Natural Science Foundation of Jiangsu Province (BK20141257), Natural Science Foundation of Yancheng Teachers University (09YCKL021, 14YCKL001) and the Fundamental Research Funds for the Central University (WY111307) for the generous financial support.

语种：英文

外文关键词：Iodine-catalyzed; Formylation; Indole; 3-Formylindole; Hexamethylenetetramine

摘要：An efficient iodine-catalyzed chemoselective 3-formylation of free (N-H) and N-substituted indoles was achieved by using hexamethylenetetramine (HMTA) in the presence of activated carbon under air atmosphere. This new method could provide 3-formylindoles in moderate to excellent yields with fairly short reaction times. Moreover, this catalytic formylation of indoles procedure can be applied to gram-scale synthesis. (C) 2017 Elsevier Ltd. All rights reserved.