文献类型：期刊文献

中文题名：不对称树状聚两性电解质的合成及pH响应性自组装行为

英文题名：Synthesis and pH-Responsive Self-Assembly Behaviors of Asymmetry Dendron-Like Polypeptide-Based Polyampholyte

作者：徐晓婵[1];陈涛[1];房文祥[1];董玉茹[1];牛磊[1];蔡春华[1]

机构：[1]华东理工大学材料科学与工程学院,上海市先进聚合物材料重点实验室,超细材料制备与应用教育部重点实验室,上海200237

年份：2016

卷号：42

期号：5

起止页码：644

中文期刊名：华东理工大学学报(自然科学版)

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：中央高校基本科研业务费专项资金(22A201514001);上海市大学生科技创新创业训练计划(S15052)

语种：中文

中文关键词：聚两性电解质;聚(L-赖氨酸);聚(L-谷氨酸);pH响应性;自组装

外文关键词：polyampholyte;poly(L-lysine);poly(L-glutamic acid);pH responsive;self-assembly

摘要：通过发散法、开环聚合以及“点击化学”等方法合成了树状聚两性电解质聚(L-赖氨酸)-聚酰胺-胺-聚(L-谷氨酸)[(PLL)4-D2-b-D1-(PLGA)2],其中,D1和D2分别代表第1代和第2代聚酰胺-胺。通过氢核磁共振波谱(^1H-NMR)、傅里叶变换红外光谱(FT-IR)和凝胶渗透色谱(GPC)对产物的分子结构、相对分子质量及其分布进行了表征;结合电位电导滴定、1H-NMR、Zeta电位测定、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和动态光散射(DLS)等表征方法研究了(PLL)4-D2-b-D1-(PLGA)2溶液的pH响应性自组装行为。研究结果表明,(PLL)4-D2-b-D1-(PLGA)2具有pH响应性多重胶束化行为,在酸性条件下形成PLL为壳、PLGA为核的聚集体,而在碱性条件下形成PLGA为壳、PLL为核的聚集体,同时伴随着PLGA和PLL链段从无规线团到α-螺旋构象的转变。随着溶液pH的增加,自组装聚集体由球形胶束向棒状胶束再向纺锤形胶束转变,并在高pH下二次自组装形成松叶状分形结构。
An asymmetry dendron-like polyampholyte,poly(L-lysine)4-D2-6-Dl-poly(L-glutamic acid)2[(PLL)4-D2-6-Dl-(PLGA)2],where D1 and D2 are the first and second generation of poly(amido amine),was synthesized via the combination of divergent synthesis procedure,ring-opening polymerization(ROP)and click chemistry.The molecular structure,molecular weight and molecular weight distribution were characterized by proton nuclear magnetic resonance spectroscopy(,1 H-NMR),Fourier transform-infrared spectroscopy(FT-IR)and gel permeation chromatograph(GPC).The pH-responsive self-assembly behaviors were investigated via potentiometric and conductometric titration,,1 H-NMR spectroscopy,zeta potential measurement,scanning electron microscopy(SEM),transmission electron microscopy(TEM)and dynamic light scattering(DLS).It was found that(PLL)4-D2-b-D1-(PLGA)2 shows pH-responsive"schizophrenic"micellization behaviors.It can self-assemble into aggregates with PLL-corona and PLGA-core at acid pH,and with PLGA-corona and PLL-core at alkaline pH,companied with the coil-to-helix conformational transition of PLGA and PLL segments.The self-assembled aggregates changed their morphology from spherical to rod-like and then to spindle-like micelles.Moreover,novel villus-like fractal structure was formed by hierarchical assembling of spindle-like micelles at high pH value.