文献类型：期刊文献

英文题名：Morphology Evolution and Spatially Selective Functionalization of Hierarchically Porous Silica Nanospheres for Improved Multidrug Delivery

作者：Li, Nan[1];Niu, Dechao[1];Jiang, Yu[1];Xu, Chuanpeng[1];Pan, Shan[1];He, Jianping[1];Chen, Jianzhuang[1];Zhang, Linlin[2];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Lab Low Dimens Mat Chem,Minist Educ, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2017

卷号：29

期号：24

起止页码：10377

外文期刊名：CHEMISTRY OF MATERIALS

收录：;EI(收录号：20175204569521);WOS:【SCI-EXPANDED(收录号:WOS:000418990700013)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Grant No. 2016YFA0203700); Shanghai Rising-Star Program (16QA1401300); NSFC (Grant Nos. 51572083, 51572084, 51461165202, 51472085); the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, 111 Project (B14018); The Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Pore structure - Cationic surfactants - Mesoporous materials - Self assembly - Thermogravimetric analysis - Nanospheres - Dyes - Differential scanning calorimetry - Silica - Morphology - Pore size

摘要：Hierarchically porous materials are believed one of the most promising matrix materials due to their unique multimodal pore structures and great application potentials in catalysis, separation, and biomedicine. In this article, a series of hierarchically porous silica nanospheres with adjustable morphologies and pore structures/sizes has been successfully developed by controlling the electrostatic interaction-induced interfacial self-assembly behaviors between anionic block copolymer polystyrene-b-poly(acrylic acid) (PS-b-PAA), cationic surfactant cetyltrimethylammonium bromide, and tetraethyl orthosilicate. Especially, "embedded" structured dual-mesoporous silica nanospheres (E-DMSNs) containing connected large mesopores (>10 nm) and abundant small mesopores (2-3 nm) in the large-pore framework have been prepared for the first time. Moreover, by employing PS-b-PAA with shorter PAA block lengths as template, the morphology conversion of porous silica nanospheres from core - shell structured dual-mesoporous silica nanospheres to well-defined hollow mesoporous silica nanospheres has been achieved. To endow the capability of E-DMSNs as multidrug delivery vehicles, a spatially selective functionalization strategy has been adopted to obtain dual-functionalized E-DMSNs (E-DMSNs-NH2/OH) with amino-functionalized large mesopores and hydroxyl-modified small mesopores. Thermogravimetric-differential scanning calorimetry analysis shows that the loading amount of curcumin (Cur) and doxorubicin hydrochloride (DOX) were about 3.4% and 10.0% in weight, respectively. In addition, the cytotoxicity assay and cellular uptake of DOX@Cur@E-DMSNs-NH2/OH on SMMC-7721 cells (human hepatoma cells) have been investigated. Thus, such a simple methodology to synthesize hierarchically porous silica with adjustable morphologies, pore sizes, and pore modifications provides a new pathway for the rational design of antitumor multidrug nanocarriers in further cancer treatment.