文献类型：期刊文献

英文题名：Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

作者：Wu, Wenbin[1];Huang, Huicai[1];Yuan, Xiaoqian[1];Zhu, Kailong[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai 200237, Peoples R China

年份：2012

卷号：48

期号：73

起止页码：9180

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000307588600022)，CCR-EXPANDED(收录号:WOS:000307588600022)】；

基金：We thank Shanghai Municipal Education Commission (11ZZ56), the National Natural Science Foundation of China (20902018), the Fundamental Research Funds for the Central Universities and the Shanghai Committee of Science and Technology (11DZ2260600) for financial support.

语种：英文

摘要：A diamine-catalyzed asymmetric tandem reaction between alpha,beta-unsaturated ketones and rhodanine derivatives has been developed to synthesize various spirocyclic compounds with high stereoselectivities (up to 99% ee and >20 : 1 dr). The products obtained contain two pharmaceutically relevant features: the biologically active rhodanine moiety embedded in a spirocyclic unit.