文献类型：期刊文献

英文题名：Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro

作者：She, Jie-Mei[1];Yuan, Hui-Hui[1,2];Zhang, Jin[3];Si, Zhao-Nian[1];Lan, Min-Bo[1,4]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Appl Chem, Shanghai 200237, Peoples R China;[3]Shanghai Putuo Hosp Tradit Chinese Med, Shanghai 200062, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：71

期号：3

起止页码：541

外文期刊名：ARCHIVES OF BIOLOGICAL SCIENCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000491998600019)】；

基金：This work was supported in part by the Fundamental Research Funds for Central Universities, No. 222201817022.

语种：英文

外文关键词：Rubus chingii Hu.; antioxidant activity; anti-photoaging; reactive oxygen species (ROS); mitogen-activated; protein kinase (MAPK) signaling pathway

摘要：Rubus chingii Hu. is an important traditional Chinese medicine with a beneficial effect on the kidney. Traditional Chinese medicine theory believes that supporting the kidney has a key role in anti-aging. To the best of our knowledge, the anti-photoaging activity of Rubus chingii Hu. has not been investigated. We investigated the anti-photoaging effects and the underlying mechanism of the ethyl acetate fraction of Rubus chingii Hu. fruit ethanol extract (E-EA) in UVB-induced human fibroblasts (HFF-1). Our results show that E-EA (10-40 mu g/mL) displayed preventive and therapeutic effects on UVB-induced cytotoxicity in HFF-1 cells. E-EA also presented significant anti-photoaging properties in UVB-induced HFF-1 cells by decreasing the levels of reactive oxygen species (ROS), inhibiting matrix metallopeptidase 1 (MMP-1) production and promoting type-I procollagen production via suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. These results suggested that E-EA might be a promising anti-photoaging agent to protect the skin from UVB damage, with a potential application in cosmetics.