文献类型：期刊文献

英文题名：Lipase-catalyzed continuous ring-opening polymerization of e-caprolactone in a packed-bed reactor

作者：Zhang, M.J.[1]; Su, E.Z.[1]; Lin, J.P.[1]; Wei, D.Z.[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China

年份：2012

卷号：26

期号：1

起止页码：1

外文期刊名：Chemical and Biochemical Engineering Quarterly

收录：EI(收录号：20121814987372)

语种：英文

外文关键词：Packed beds - Chemical reactors - Polydispersity - Monomers - Catalysis

摘要：A packed-bed reactor (PBR) system was developed for continuous lipase-catalyzed ring-opening polymerization of Ε-caprolactone (Ε-CL). The parameters affecting the poly(Ε-caprolactone) (PCL) production in the PBR such as residence time, height to diameter (H/D) ratio, and monomer feed concentration were investigated. Monomer conversion of Ε-CL increased with the increase of residence time, reached the highest (over 98 %) at the residence time of 12 min. And under this residence time it would almost not change even if the H/D ratio varied from 4 to 20 or the monomer concentration varied from 0.2 to 2.25 mol L-1. The number-average molecular mass (Mn) of PCL did not change in agreement with the monomer conversion, and approached the maximal values of 15600 g mol-1 with polydispersity index (PDI) of 2.1 under 20 min residence time, 12.0 H/D ratio and 1.75 mol L-1 monomer concentration. The Mn of PCL maintained around 15600 g mol-1 without appreciable loss during the long-term operation of 460 h with the PCL productivity of 19.15 g g-1 enzyme d-1).