文献类型：期刊文献

英文题名：Supramolecular aggregates from polyacrylates and Gd(III)-containing cationic surfactants as high-relaxivity MRI contrast agents

作者：Chen, Yingying[1];Zhu, Qin[1];Tian, Yu[2];Tang, Weijun[3];Pan, Fei[1];Xiong, Rulin[1];Yuan, Yuan[2];Hu, Aiguo[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China

年份：2015

卷号：6

期号：9

起止页码：1521

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20150900569333);WOS:【SCI-EXPANDED(收录号:WOS:000349832300011)】；

基金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (21274042) and the Shanghai Leading Academic Discipline Project (B502). AH acknowledges the "Eastern Scholar Professorship" support from the Shanghai local government.

语种：英文

外文关键词：Gadolinium compounds - Magnetic resonance imaging - Molecular weight - Cationic surfactants - Biocompatibility - Polyelectrolytes - Dyes

摘要：The assembly behavior of narrowly dispersed poly(sodium acrylate) (PAAS) of different molecular weights with Gd(III)-containing cationic metallosurfactants (MS) was investigated by DLS, TEM and relaxivity plotting. The formed polyelectrolyte-surfactant complexes (PSCs) showed different structural patterns as the charge ratio increased from micellar to vesicular structures. SEM element mapping showed the presence of the gadolinium element in these complexes. An ICP-AES analysis further quantified the contents of Gd(III) in the PSCs. T-1 magnetic resonance imaging (MRI) showed that these Gd(III)-loading complexes exhibited a relaxivity of up to 21.89 mM(-1) s(-1), much higher than that of Omniscan (R) (4.64 mM(-1) s(-1)). A higher relaxivity was achieved with PAAS of higher molecular weight at the same charge ratio. The cytotoxicity test in vitro demonstrated the excellent biocompatibility of these PSCs, which is essential for clinical application.