文献类型：期刊文献

英文题名：Direct preparation of drug-loaded mesoporous silica nanoparticles by sequential flash nanoprecipitation

作者：Fu, Zhinan[1];Li, Li[1];Wang, Yiming[1,2];Chen, Qiaolin[1];Zhao, Fang[1];Dai, Liheng[1];Chen, Zhuo[1];Liu, Dianhua[1];Guo, Xuhong[1,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Delft Univ Technol, Dept Chem Engn, Maasweg 9, NL-2629 HZ Delft, Netherlands;[3]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Xinjiang 832000, Peoples R China

年份：2020

卷号：382

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20194007496066);WOS:【SCI-EXPANDED(收录号:WOS:000503381200070)】；

基金：The work was financially supported by the NSFC Grants (51761135128 and 51773061), Key Scientific and Technological Project of Xinjiang Bingtuan (2018AB025), and the Fundamental Research Funds for the Central Universities (22221818010 and 222201917013).

语种：英文

外文关键词：Mesoporous silica nanoparticles; Sequential flash nanoprecipitation; Abamectin; Drug delivery

摘要：The present work demonstrates how drug-loaded mesoporous silica nanoparticles (MSNPs) can be prepared by a sequential flash nanoprecipitation (FNP) technique. A sequential FNP technique is developed relying on a combination of two multi-inlet vortex mixers (MIVM), by which a continuous process that involves the formation of micelle-based templates followed by an in situ formation of MSNPs is achieved. Moreover, a widely used biological nematicide, abamectin (Abm), is added during the formation of micelles, ultimately leading to Abm-loaded MSNPs with high encapsulation efficiency. The obtained Abm-loaded MSNPs show excellent stability and inhibition activity against the livability of Meloidogyne incognita. Importantly, the parameters of the resulting MSNPs, such as silica shell thickness and inner cavity size of MSNPs, can be easily controlled by tuning the compositions of the reactant streams. We believe that such a simple approach towards direct preparation of drug-loaded MSNPs would find promising up-scale applications in various fields, such as drug delivery, bioimaging, and formulation technology.