文献类型：期刊文献

英文题名：pH and Temperature Double-Switch Hybrid Micelles for Controllable Drug Release

作者：Lei, Bin[1,2];Sun, Minjia[1,2];Chen, Miaoxin[1,2];Xu, Shouhong[1,2];Liu, Honglai[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：37

期号：50

起止页码：14628

外文期刊名：LANGMUIR

收录：;EI(收录号：20215011330308);WOS:【SCI-EXPANDED(收录号:WOS:000731059200001)】；

基金：This work was supported by the National Natural Science Foundation of China (nos. 22078087 and 21776071).

语种：英文

外文关键词：Biocompatibility - Controlled drug delivery - Micelles - Polyethylenes - Polyethylene oxides - Targeted drug delivery - Amides - Stability

摘要：pH/temperature dual-responsive hybrid micelles were prepared for constructing a double-locked drug delivery system. The temperature-sensitive polyethylene glycol-poly-(tetrahydropyranylmethacrylate)-polyethylene glycol (PEG - PTHPMA-PEG) triblock copolymers were synthesized by reversible addition-fragmentation chain transfer polymerization and amide coupling reaction. pH-sensitive poly(2-(diisopropylamino ethylmethacrylate)-polyethylene glycol (PDPA-PEG) di-block polymers were introduced, which could self-assemble with PEG-PTHPMA-PEG in aqueous solutions to form hybrid micelles. The anticancer drug doxorubicin, which was encapsulated in the core of the hybrid micelles, could be released only under simultaneous stimulations of pH and temperature. It was proved that the micelles could maintain their structural stability under a unilateral stimulus, while the structure collapsed and recombined under a double stimulus, which triggered a large amount of drug release. Furthermore, the excellent biocompatibility and dual sensitivity of the vector were also proved by cytotoxicity experiments. The dual-responsive hybrid micelles designed here showed the advantages of a double insurance lock of drug leakage and precise controllability of drug release, which could act as accurate drug delivery systems.