文献类型：期刊文献

中文题名：Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

作者：Jianye Xia[1];Guan Wang[1];Meng Fan[1];Min Chen[1];Zeyu Wang[1];Yingping Zhuang[1]

机构：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China

年份：2021

卷号：34

期号：2

起止页码：178

中文期刊名：Chinese Journal of Chemical Engineering

外文期刊名：中国化学工程学报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；

基金：The authors would like to acknowledge the Projects 21776082 and 21978085 supported by National Natural Science Foundation of China;Project 22221818014 supported by the Fundamental Research Funds for the Central Universities.

语种：英文

中文关键词：Fermentation;Scale-up;Bioreactors;Gas-liquid flow;Kinetics

摘要：The production capability of a fermentation process is predominately determined by individual strains,which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains.Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process.We review these two aspects and address progress in strategies for scaling up fermentation processes.A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.