文献类型：期刊文献

中文题名：三七真空冷冻干燥工艺优化及对活性成分影响的研究

英文题名：Optimization of Vacuum Freeze-Drying Process of Panax notoginseng and Its Effect on Active Ingredients

作者：刘胜男[1];王承潇[1];杨野[1];杨晓艳[1];韩伟[2];崔秀明[1,3]

机构：[1]昆明理工大学生命科学与技术学院,昆明650500;[2]华东理工大学药学院,制药工程与过程化学教育部工程研究中心,上海200237;[3]云南省三七重点实验室,昆明650500

年份：2020

卷号：46

期号：4

起止页码：517

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD_E2019_2020】；

基金：国家重点研发计划(2017YFC1702503);云南省三七资源可持续利用重点实验室项目(JK201903131248)。

语种：中文

中文关键词：三七;真空冷冻干燥;质量评价;单因素试验;响应面分析法

外文关键词：Panax notoginseng;vacuum freeze-drying;quality evaluation;single-factor experiment;response surface analysis

摘要：以三七总皂苷(PNS)和三七素两种成分的质量分数为评价指标,采用中心组合设计(CCD)结合响应面进行分析,并通过扫描电子显微镜(SEM)对三七饮片进行质量评价。通过单因素试验及交互作用的考察发现,在优化的工艺条件(真空压强56.9 Pa,隔板温度45.2℃)下,PNS质量分数为9.77%,三七素质量分数为1.76%。满意度函数结合CCD得出理论最大满意度值为4.353,3次验证试验平均值为4.276,与理论最大满意度值相近。对比其他单因素条件,在真空压强为56.9 Pa,隔板温度为45.2℃下指标成分的质量分数最高。
Influences of vacuum freeze-drying on the active constituent of Panax notogiseng(P.notoginseng)and the optimal drying process with the content of Panax notoginseng Saponins(PNS)and Dencichine were investigated.The single factor experiment was utilized combining with response surface methodology and satisfaction function to optimize the drying process of P.notoginseng.On the basis of single factor experiments,different optimum conditions including clapboard temperature and vacuum pressure were selected,and the method of response surface analysis was adopted according to the central composite design(CCD)experimental design principles.In addition,the P.notoginseng quality was evaluated by scanning electron microscope(SEM).The optimum drying conditions of the P.notoginseng are as follows:vacuum pressure of 56.9 Pa,the clapboard temperature of 45.2℃.Under the optimal drying conditions,the mass content of PNS and Dencichine could reach 9.77%and 1.76%,respectively.The satisfaction function results showed that the maximum value of the optimum process conditions was 4.353,and the values of three parallel experiments are similar to the optimum model.This technology could be used to guide industrial production of P.notoginseng and provide a theoretic basis.