文献类型：期刊文献

英文题名：Fabrication and evaluation of chiral monolithic column modified by β-cyclodextrin derivatives

作者：Li, Yingjie[1,2];Song, Chunhui[2];Zhang, Lingyi[3];Zhang, Weibing[3];Fu, Honggang[1]

机构：[1]Heilongjiang Univ, Minist Educ Peoples Republ China, Key Lab Funct Inorgan Mat Chem, Harbin 150080, Heilongjiang, Peoples R China;[2]Qiqihar Univ, Coll Chem & Chem Engn, Qiqihar 161006, Peoples R China;[3]E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2010

卷号：80

期号：3

起止页码：1378

外文期刊名：TALANTA

收录：;EI(收录号：20095112555684);WOS:【SCI-EXPANDED(收录号:WOS:000273929900051)】；

基金：We gratefully acknowledge the support of this research by the Key Program Projects of the National Natural Science Foundation of China (No. 20431030), the National Natural Science Foundation of China (No. 20671032), The Cultivation Fund of the Key Scientific and Technical Innovation Project, Ministry of Education of China (No. 708029), the Key Program Projects of the Province Natural Science Foundation of Heilongjiang Province (No. ZJG0602-01).

语种：英文

外文关键词：Capillary electrochromatography; Chiral separation; beta-Cyclodextrin; Derivative; Monolith

摘要：Based on combination of chiral recognition ability of beta-cyclodextrin (beta-CD) derivatives and flexibility of monolithic material, a series of chiral stationary phases (CSPs) were prepared by the immobilization of beta-CD and three of its derivatives to the epoxy-activated poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith under mild condition. Immobilization condition for the connection reaction by different functional groups and bonding ways was studied to obtain good enantiomer selectivity. Prepared CSPs were evaluated by separating racemic mixtures of eight amino acids and two chiral drugs with capillary electrochromatography (CEC). (C) 2009 Elsevier B.V. All rights reserved.