文献类型：期刊文献

英文题名：Advancing Artificial Cells with Functional Compartmentalized Polymeric Systems - In Honor of Wolfgang Meier

作者：Palivan, Cornelia G.[1];Heuberger, Lukas[1];Gaitzsch, Jens[2];Voit, Brigitte[2];Appelhans, Dietmar[2];Fernandes, Barbara Borges[3,4];Battaglia, Giuseppe[3,5];Du, Jianzhong[6,7];Abdelmohsen, Loai[8];van Hest, Jan C. M.[8];Hu, Jinming[9,10];Liu, Shiyong[9,10];Zhong, Zhiyuan[11,12,13];Sun, Huanli[11];Mutschler, Angela[14];Lecommandoux, Sebastien[14]

机构：[1]Univ Basel, Dept Chem, CH-4002 Basel, Switzerland;[2]Leibniz Inst Polymerforsch Dresden eV, D-01069 Dresden, Germany;[3]Barcelona Inst Sci & Technol, Inst Bioengn Catalonia, Barcelona 08028, Spain;[4]Univ Barcelona, Dept Condensed Matter Phys, E-08028 Barcelona, Spain;[5]Catalan Inst Res & Adv Studies, Barcelona 08010, Spain;[6]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[7]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[8]Eindhoven Univ Technol, Inst Complex Mol Syst, Dept Chem & Chem Engn, Bioorgan Chem, NL-5600MB Eindhoven, Netherlands;[9]Univ Sci & Technol China USTC, Affiliated Hosp 1, Dept Pharm, Div Life Sci & Med, Hefei 230026, Anhui, Peoples R China;[10]Univ Sci & Technol China, Dept Polymer Sci & Engn, Lab Precis & Intelligent Chem, Hefei 230026, Anhui, Peoples R China;[11]Soochow Univ, Coll Chem Chem Engn & Mat Sci, Biomed Polymers Lab, State Key Lab Radiat Med & Protect, Suzhou 215123, Peoples R China;[12]Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China;[13]Soochow Univ, Int Coll Pharmaceut Innovat, Suzhou 215123, Peoples R China;[14]Univ Bordeaux, Bordeaux INP, CNRS, UMR 5629,LCPO, F-33600 Pessac, France

年份：2024

卷号：25

期号：9

起止页码：5454

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20243616977832);WOS:【SCI-EXPANDED(收录号:WOS:001300761300001)】；

基金：This work was partly supported by the European Union's Horizon Europe Research and Innovation Program under the Grant Agreement No. 101079482 ("SUPRALIFE"),the National Natural Science Foundation of China (21925505, 22335005), the international scientific collaboration fund of Science and Technology Commission of Shanghai Municipality (21520710100), and the Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28). The ANR TEPEE and ANR PopART are also acknowledged for financial support together with Univ. Bordeaux and Bordeaux INP. This study was financially supported by The Netherlands Ministry of Education, Culture and Science(Gravitation Program Interactive Polymer Materials 024.005.020, and the Spinoza premium SPI 72-259), the Swiss National Science Foundation(SNSF, Grant No. 207383), and the University of Basel.

语种：英文

外文关键词：Biocommunications - Biomolecules - Cell culture

摘要：The fundamental building block of living organisms is the cell, which is the universal biological base of all living entities. This micrometric mass of cytoplasm and the membrane border have fascinated scientists due to the highly complex and multicompartmentalized structure. This specific organization enables numerous metabolic reactions to occur simultaneously and in segregated spaces, without disturbing each other, but with a promotion of inter- and intracellular communication of biomolecules. At present, artificial nano- and microcompartments, whether as single components or self-organized in multicompartment architectures, hold significant value in the study of life development and advanced functional materials and in the fabrication of molecular devices for medical applications. These artificial compartments also possess the properties to encapsulate, protect, and control the release of bio(macro)molecules through selective transport processes, and they are capable of embedding or being connected with other types of compartments. The self-assembly mechanism of specific synthetic compartments and thus the fabrication of a simulated organelle membrane are some of the major aspects to gain insight. Considerable efforts have now been devoted to design various nano- and microcompartments and understand their functionality for precise control over properties. Of particular interest is the use of polymeric vesicles for communication in synthetic cells and colloidal systems to reinitiate chemical and biological communication and thus close the gap toward biological functions. Multicompartment systems can now be effectively created with a high level of hierarchical control. In this way, these structures can not only be explored to deepen our understanding of the functional organization of living cells, but also pave the way for many more exciting developments in the biomedical field.