文献类型：期刊文献

英文题名：Hyaluronic acid conjugated polydopamine functionalized mesoporous silica nanoparticles for synergistic targeted chemo-photothermal therapy

作者：Chen, Chao[1];Tang, Wen[1];Jiang, Dawei[2];Yang, Guoliang[2];Wang, Xiaoli[1];Zhou, Lina[1];Zhang, Weian[2];Wang, Ping[1,3]

机构：[1]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, Biomed Nanotechnol Ctr, State Key Lab Bioreactor Engn,Sch Biotechnol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA

年份：2019

卷号：11

期号：22

起止页码：11012

外文期刊名：NANOSCALE

收录：;EI(收录号：20192407040620);WOS:【SCI-EXPANDED(收录号:WOS:000470756000044)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 31471659, 21636003 and 21672065), Shanghai Sailing Program (No. 19YF1410900), and the Fundamental Research Funds for the Central Universities (No. 22221818014). The authors thank the Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：Disease control - Mammals - Diseases - Infrared devices - Light absorption - Silica nanoparticles - Tumors - Cancer cells - Organic acids - Hyaluronic acid

摘要：The integration of chemotherapy and photothermal therapy into one nanoplatform has attracted much attention for synergistic tumor treatment, but the practical clinical applications were usually limited by their synergistic effects and low selectivity for disease sites. To overcome these limitations, a tumorspecific and pH/NIR dual-responsive multifunctional nanocarrier coated with mussel inspired polydopamine and further conjugated with targeting molecular hyaluronic acid (HA) was designed and fabricated for synergistic targeted chemo-photothermal therapy. The synthesized versatile nanoplatform displayed strong near-infrared absorption because of the successful formation of polydopamine coating. Furthermore, the nanosystem revealed high storage capacity for drugs and pH/NIR dual-responsive release performance, which could effectively enhance the chemo-photothermal therapy effect. With this smart design, in vitro experimental results confirmed that the drug loaded multifunctional nanoparticles could be efficiently taken up by cancer cells, and exhibited remarkable tumor cell killing efficiency and excellent photothermal properties. Meanwhile, significant tumor regression in the tumor-bearing mice model was also observed due to the combination of chemotherapy and photothermal therapy. Thus, this work indicated that the simple multifunctional nanoplatform can be applied as an efficient therapeutic agent for site-specific synergistic chemo-photothermal therapy.