文献类型：期刊文献

中文题名：Effective utilization of wastewater for valuable validamycin A biosynthesis by Streptomyces hygroscopicus K2509 in plant-scale bioreactor

作者：Wei Zou[1,2];Xiaohua Wang[3];Ali Mohsin[1];Xiwei Tian[1];Meijin Guo[1];Huamei Liu[2];Li Zhang[3];Siliang Zhang[1];Yingping Zhuang[1]

机构：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,P.O.Box 329#,130 Meilong Rd.,Shanghai 200237,People’s Republic of China;[2]Wuhan Kernel Bio-tech Co.Ltd.,GrandPharma(China)Co.,Ltd.,Wuhan,People’s Republic of China;[3]Hubei Provincial Institute for Food Supervision and Test,Wuhan 430071,People’s Republic of China

年份：2018

卷号：5

期号：1

起止页码：430

中文期刊名：Bioresources and Bioprocessing

外文期刊名：生物资源与生物加工(英文)

基金：funded by the Wuhan Kernel Bio-tech Co.,Ltd.(P.R.China);by the National key research and development programs:2017YFF0204602 and 2017ZX07402003.

语种：英文

中文关键词：Fermentation;Wastewater;Validamycin A;Plant-scale bioreactor;Cost effective

摘要：Background:The continuous escalation in wastewater production with declining dependency on conventional resources as a result of rapid urbanization,increasing global water scarcity and growing population have initiated many researchers to look out for efficient means of utilizing wastewater.In this regard,an effectual process economizing approach has been achieved,upon utilizing the discharged wastewater from validamycin A recovery process in fermentation medium as a replacement of costly tap water.Results:In this study,wastewater was successfully used as a fermentation medium for the production of validamycin A in plant-scale bioreactor.Moreover,a new strain Streptomyces hygroscopicusK2509 was screened showing a good production capability in this low-cost culture environment and showed maximum validamycin A production and productivity of 21.23 g/L and 0.29 g/L·h,respectively.Execution of this study has managed the effective utilization of wastewater by reducing 12.42%production cost per kilogram of validamycin A in an environmentally friendly way.Conclusion:The novel successful approach for using process wastewater even when executed in plant-scale bioreactor was proved cost effective.In short,the presented effective way of utilizing wastewater in this study will definitely serve as a potentially cheap fermentation medium upon replacing the extensively used expensive tap water.