文献类型：期刊文献

英文题名：DNAzyme- and light-induced dissipative and gated DNA networks

作者：Wang, Jianbang[1];Li, Zhenzhen[1];Zhou, Zhixin[1];Ouyang, Yu[1];Zhang, Junji[2];Ma, Xiang[2];Tian, He[2];Willner, Itamar[1]

机构：[1]Hebrew Univ Jerusalem, Ctr ForNanosci & Nanotechnol, Inst Chem, IL-91904 Jerusalem, Israel;[2]East China Univ Sci & Technol, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Key Lab Adv Mat,Feringa Nobel Prize Scientist Joi, Shanghai 200237, Peoples R China

年份：2021

卷号：12

期号：33

起止页码：11204

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20213510836174);WOS:【SCI-EXPANDED(收录号:WOS:000678159100001)】；

基金：This study is supported by the Israel Science Foundation (IW) and by the National Natural Science Foundation of China (NSFC, 22020102006).

语种：英文

外文关键词：Fuels - Nucleic acids

摘要：Nucleic acid-based dissipative, out-of-equilibrium systems are introduced as functional assemblies emulating transient dissipative biological transformations. One system involves a Pb2+-ion-dependent DNAzyme fuel strand-driven network leading to the transient cleavage of the fuel strand to "waste" products. Applying the Pb2+-ion-dependent DNAzyme to two competitive fuel strand-driven systems yields two parallel operating networks. Blocking the competitively operating networks with selective inhibitors leads, however, to gated transient operation of dictated networks, yielding gated catalytic operations. A second system introduces a "non-waste" generating out-of-equilibrium, dissipative network driven by light. The system consists of a trans-azobenzene-functionalized photoactive module that is reconfigured by light to an intermediary state consisting of cis-azobenzene units that are thermally recovered to the original trans-azobenzene-modified module. The cyclic transient photoinduced operation of the device is demonstrated. The kinetic simulation of the systems allows the prediction of the transient behavior of the networks under different auxiliary conditions.