文献类型：期刊文献

英文题名：CuBr-mediated radical cascade difluoroacetamidation of acrylamides using α,α-difluoro-α-(TMS)-acetamides

作者：Liu, Kai;Sui, Lin-Chao;Jin, Qiao;Li, Deng-Yuan;Liu, Pei-Nian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Meilong Rd 130, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2017

卷号：4

期号：8

起止页码：1606

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20184806137138);WOS:【SCI-EXPANDED(收录号:WOS:000406374800020)，CCR-EXPANDED(收录号:WOS:000406374800020)】；

基金：This work was supported by the National Natural Science Foundation of China (Project no. 21372072, 21421004, 21561162003 and 21672059), the Eastern Scholar Distinguished Professor Program and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：Radical cascade difluoroacetamidation of N-(arylsulfonyl) acrylamides with alpha, alpha-difluoro-alpha-(TMS)-aceta-mides has been achieved for the first time. This CuBr-mediated transformation is easy to perform, generates high yields and shows a good substrate scope. This cascade reaction proceeds via difluoroacetamidation, aryl migration and desulfonylation. The products can be readily transformed into synthetically useful compounds such as difluorofunctionalized esters and alcohols in excellent yields.