文献类型：期刊文献

英文题名：CCE and EODF as two distinct non-shivering thermogenesis models inducing weight loss

作者：Xu, Tianyi[1];Wang, Juan[2];Shi, Hongwei[1];Wei, Xiaofang[1];Zhang, Huiling[1];Ji, Yunyan[1];Lu, Shiting[3];Yan, Yi[1];Yu, Xiuju[1];Luo, Xiaomao[1];Wang, Haidong[1]

机构：[1]Shanxi Agr Univ, Coll Vet Med, Taigu 030801, Shanxi, Peoples R China;[2]Shanghai Jiao Tong Univ, Dept Nephrol, Shanghai Gen Hosp, Sch Med, Haining Rd, Shanghai 200080, Peoples R China;[3]East China Univ Sci & Technol, Sch Foreign Languages, Shanghai 200237, Peoples R China

年份：2023

卷号：475

期号：8

起止页码：961

外文期刊名：PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001022081600001)】；

基金：This study was supported by the National Natural Science Foundation of China (No. 82170751, 32102634), the Fund for Shanxi "1331 Project" (No. 20211331-16, 20211331-13, 20211331-12), the "Six New" Project of Agriculture and Rural Department of Shanxi Province, the Young Science Foundation of Shanxi province, China (Grant No. 201901D211368, No.20210302124700), the Start-Up Fund for doctoral research, Shanxi Agricultural University (Grant No. 2018YJ46, 2021BQ08), the Shanxi Province Excellent Doctoral Work Award-Scientific Research Project (Grant No. SXYBKY2019001, SXBYKY2021043), and the Innovation Projects of College of Veterinary Medicine, Shanxi Agricultural University (Grant No. DY-M007).

语种：英文

外文关键词：Weight loss; Lipid metabolism; Non-shivering thermogenesis; Every-other-day fasting; Chronic cold exposure; FGF21-ADPN axis

摘要：Increasing energy expenditure and reducing energy intake are considered two classical methods to induce weight loss. Weight loss through physical methods instead of drugs has been a popular research topic nowadays, but how these methods function in adipose and cause weight loss in body remains unclear. In this study, we set up chronic cold exposure (CCE) and every-other-day fasting (EODF) as two distinct models in long-term treatment to induce weight loss, recording their own characteristics in changes of body temperature and metabolism. We investigated the different types of non-shivering thermogenesis induced by CCE and EODF in white and brown adipose tissue through sympathetic nervous system (SNS), creatine-driven pathway, and fibroblast growth factor 21 (FGF21)-adiponectin axis. CCE and EODF could reduce body weight, lipid composition, increase insulin sensitivity, promote the browning of white fat, and increase the expression of endogenous FGF21 in adipose tissue. CCE stimulated the SNS and increased the thermogenic function of brown fat, and EODF increased the activity of protein kinase in white fat. In this study, we further explained the thermogenic mechanism function in adipose and metabolic benefits of the stable phenotype through physical treatments used for weight loss, providing more details for the literature on weight loss models.