文献类型：期刊文献

英文题名：Development of an Escherichia coli-based diterpenoid bioproduction foundry

作者：Guo, Ke[1,2]; Liu, Ping[2]; Wang, Ziwei[2]; Wang, Shiwei[1]; Wei, Jinshuo[1,2]; Zhang, Ziyang[3]; Zhao, Chuanfu[2]; Qin, Qiumei[1,2]; Zhang, Lixin[4]; Li, Zhenghong[1,2]; Wang, Weishan[5]

机构：[1] The College of Life Sciences, Ministry of Education, Northwest University, Xi'an, China; [2] R&D Innovation Center, Ingia Biosyntech Co., Ltd, Chengdu, China; [3] The School of Pharmacy, Tianjin Medical University, Tianjin, China; [4] State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, China; [5] State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

年份：2026

卷号：547

外文期刊名：Chemical Engineering Journal

收录：EI(收录号：20260189997);Scopus(收录号：2-s2.0-105047663797)

语种：英文

外文关键词：Biochemical engineering - Escherichia coli - Genes - Genetic engineering - Modular construction - Strain

摘要：Microbial heterologous production of diterpenoids is frequently constrained by the intricate assembly of multienzyme pathways, host-specific metabolic flux imbalances, and intermediate toxicity, leading to lengthy development cycles and low conversion yields. In particular, diterpenoid titers reported in the prokaryotic model workhorse E. coli were substantially lower ( ? 2026 Elsevier B.V.