文献类型：期刊文献

英文题名：Preparation, characterization, cellular response and in vivo osseointegration of polyetheretherketone/nano-hydroxyapatite/carbon fiber ternary biocomposite

作者：Deng, Yi[1,2,3];Zhou, Ping[1,2,3];Liu, Xiaochen[3];Wang, Lixin[4];Xiong, Xiaoling[1];Tang, Zhihui[2];Wei, Jie[5];Wei, Shicheng[1,2,3]

机构：[1]Peking Univ, Dept Oral & Maxillofacial Surg, Sch & Hosp Stomatol, Beijing 100081, Peoples R China;[2]Peking Univ, Sch & Hosp Stomatol, Dent Ctr 2, Beijing 100081, Peoples R China;[3]Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China;[4]Capital Med Univ, Beijing Shijitan Hosp, Beijing 100038, Peoples R China;[5]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2015

卷号：136

起止页码：64

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20153701270984);WOS:【SCI-EXPANDED(收录号:WOS:000367408100009)】；

基金：This work was supported by grants from the National Key Basic Research Program of China (No. 2007CB936103) and Peking University's 985 Grant.

语种：英文

外文关键词：Polyetheretherketone; Hydroxyapatite; Ternary composite; Osseointegration; Orthopedic

摘要：As FDA-approved implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as bioactive implant material in dental and orthopedic applications. (C) 2015 Elsevier B.V. All rights reserved.