文献类型：期刊文献

英文题名：Antibacterial properties of mesoporous copper-doped silica xerogels

作者：Wu, Xiaohui[1,2];Ye, Liang[3];Liu, Kun[1,2];Wang, Wei[1,2];Wei, Jie[1,2];Chen, Fangping[1,2];Liu, Changsheng[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]Sun Yat Sen Univ, Guanghua Sch Stomatol, Guangzhou 510275, Guangdong, Peoples R China

年份：2009

卷号：4

期号：4

外文期刊名：BIOMEDICAL MATERIALS

收录：;EI(收录号：20093512275988);WOS:【SCI-EXPANDED(收录号:WOS:000268871000017)】；

基金：This study was supported by the National Natural Science Funds of China (no. 30670568), Nano special program of Science and Technology Development of Shanghai (no. 0852nm02700), Standard special program of Science and Technology Development of Shanghai (no. 08DZ0501600). Moreover, we are grateful to Ms Huanjun Zhou, Hua Hong and Dai Chenglong for their help in preparing this paper.

语种：英文

外文关键词：Heavy ions - Synthesis (chemical) - Sol-gel process - Escherichia coli - Silica gel - Mesoporous materials - Pore size - Xerogels

摘要：Mesoporous copper-doped silica xerogels (m-SXCu) with antibacterial properties were synthesized by a sol-gel process, and the morphology, structure and composition of m-SXCu were characterized. The results show that m-SXCu5 with a high surface area of 463.1 m(2) g(-1) have a mesoporous structure with a pore size of about 2 nm. The addition of Cu from 1 to 5 wt% to m-SXCu had a slight effect on the surface area and a not-so-obvious effect on the mesoporous size of m-SXCu. Cu ions can be released from m-SXCu into the simulated body fluid, and the release rate depends significantly on their number. The m-SXCu possessed good antibacterial activity against both E. coli and S. aureus, in which the antibacterial rate reached 99% for m-SXCu5 at 1 h while reaching 99% for all m-SXCu at 24 h. The antibacterial rate was improved with the increase of the amount of Cu, indicating that addition of Cu ions to m-SX enhanced its antibacterial activity.