文献类型：期刊文献

中文题名：蓝藻为载体的阿维菌素抗紫外缓释剂的制备及其性能

英文题名：Preparation of Anti-UV Controlled Release Formulation of Avermectin with Carrier of Blue Algae and Its Property

作者：侯宏伟[1];任天瑞[1];燕云峰[1];王全喜[1];徐文平[2]

机构：[1]上海师范大学生命与环境科学学院,上海200234;[2]华东理工大学药学院,上海200237

年份：2011

卷号：11

期号：5

起止页码：846

中文期刊名：过程工程学报

外文期刊名：The Chinese Journal of Process Engineering

收录：CSTPCD;;Scopus;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金资助项目(编号:20872093);国家高技术研究发展计划(863)基金资助项目(编号:2011AA100503);国家十二五科技支撑计划基金资助项目(编号:2011BAE06B06);上海市教委资助项目(编号:11ZZ122);上海市重点学科基金资助项目(编号:S30406)

语种：中文

中文关键词：蓝藻;阿维菌素;抗紫外缓释剂

外文关键词：blue algae; avermactin; adsorption; anti-UV controlled release formulation

摘要：以滇池蓝藻为载体,利用其抗紫外特性,用卡波姆树脂包裹蓝藻?阿维菌素(Avermectin,Av)粉,制成阿维菌素抗紫外缓释剂,利用FT-IR,SEM和HPLC等对蓝藻和缓释剂进行表征,研究其吸附与释放行为.结果表明,Av在异丙醇中的饱和吸附量为160.81mg/g,包裹10%卡波姆树脂的抗紫外缓释剂具有很好的缓释功能,在乙醇/水(4:1,φ)中释放20d,累计释放率为51.8%,释放机制是Fick扩散和骨架溶蚀的双重机制.经4h紫外光照射,含蓝藻的制剂中Av残留量为61%,不含蓝藻的制剂中Av残留量为39%.
A major objective of the present work is to develop anti-UV controlled release formulation of avermectin（Av）,with utilizing the anti-UV characteristic of blue algae as carrier taken from Dianchi Lake.Av was adsorbed on blue algae powder and then coated with 10% carbomer resin.The blue algae powder and release formulation were characterized by FT-IR,SEM and HPLC.The results show that the adsorptive capacity of Av is 160.81 mg/g in isopropanol at 25℃.The formulation release rate is 51.8% for 20 d in ethanol/water（4：1,j） at 25℃.The controlled release mechanism belongs to Fickian diffusion and matrix erosion.The residual rates of Av with blue algae and alone are 61.0% and 39.0% respectively under UV irradiating.It is improved that blue algae has the function of resistance against UV.