文献类型：期刊文献

英文题名：Asymmetric synthesis of pyrano[2,3-c]pyrazoles via a cascade reaction between Morita-Baylis-Hillman acetates of nitroalkenes and pyrazolones

作者：Xie, Jin;Sha, Feng;Wu, Xin-Yan[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2016

卷号：72

期号：27-28

起止页码：4047

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000378470800033)，CCR-EXPANDED(收录号:WOS:000378470800033)】；

基金：We are grateful for the financial support from National Natural Science Foundation of China (21102043), Science and Technology Commission of Shanghai Municipality (15ZR1409200), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Cascade reaction; Enantioselective organocatalysis; MBH acetates; Pyrano[2,3-c]pyrazoles; Squaramide

摘要：The first organocatalytic enantioselective cascade reaction of Morita-Baylis-Hillman acetates of nitroalkenes with pyrazolones has been developed. With 20 mol % of chiral tertiary-amine squaramide, 1,4,5,6-tetrahydropyrano[2,3-c]pyrazoles were afforded in moderate yields (up to 71%) with excellent stereoselectivities (up to>99:1 dr and up to 98% ee). (C) 2016 Elsevier Ltd. All rights reserved.