文献类型：期刊文献

英文题名：Harnessing strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns

作者：Cai, Yixin[1];Chen, Kangli[1];Liu, Changsheng[1];Qu, Xue[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn, Key Lab Ultrafine Mat Minist Educ, Shanghai 200237, Peoples R China;[2]Wenzhou Inst Shanghai Univ, Wenzhou 325000, Peoples R China;[3]Shanghai Frontier Sci Ctr Optogenet Tech Cell Meta, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, 130 Meilong Rd, Shanghai, Peoples R China

年份：2023

卷号：28

起止页码：243

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001017493300001)】；

基金：Support from the National Natural Science Foundation of China (31922041, 11932012, 32171341), National key research and development program (2021YFB3800800), the 111 project (B14018), the Science and Technology Innovation Project and Excellent Academic Leader Project of Shanghai Science and Technology Committee (21S31901500, 21XD1421100) are acknowledged.

语种：英文

外文关键词：Diabetic wound; Spatial inflammation pattern; M1; M2 transition; Biomaterials

摘要：Diabetic wound is a great threat to patient's health and lives. The refractory diabetic wound shows spatial inflammation patterns, in which the early-wound pattern depicts a deprived acute inflammatory response, and the long-term non-healing wound pattern delineates an excessive and persistent inflammation due to the delayed immune cell infiltration in a positive feedback loop. In this work, we give points to some strategies to normalize the dysregulated immune process based on the spatial inflammation pattern differences in diabetic wound healing. First of all, inhibiting inflammatory response to avoid subsequent persistent and excessive immune infiltration for the early diabetic wound is proposed. However, diabetic wounds are unperceptive trauma that makes patients miss the best treatment time. Therefore, we also introduce two strategies for the long-term non-healing diabetic wound. One strategy is about changing chronic wounds to acute ones, which aims to rejuvenate M1 macrophages in diabetic wounds and make spontaneous M2 polarization possible. To activate the control-lable proinflammatory response, western medicine delivers proinflammatory molecules while traditional Chinese medicine develops "wound-pus promoting granulation tissue growth theory". Another strategy to solve long-term non-healing wounds is seeking switches that target M1/M2 transition directly. These investigations draw a map that delineates strategies for enhancing diabetic wound healing from the perspective of spatial inflam-mation patterns systematically.