文献类型：期刊文献

英文题名：Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability

作者：Wang, Bin[1];Pan, Rizhao[1];Zhu, Weiping[1];Xu, Yufang[1];Tian, Ye[2];Endo, Masayuki[3];Sugiyama, Hiroshi[3];Yang, Yangyang[1];Qian, Xuhong[1,4]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210093, Peoples R China;[3]Kyoto Univ, Dept Chem, Kitashirakawa Oiwakecho, Kyoto 6068502, Japan;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：17

期号：5

起止页码：1184

外文期刊名：SOFT MATTER

收录：;EI(收录号：20210809945638);WOS:【SCI-EXPANDED(收录号:WOS:000618043500004)】；

基金：This work was supported by the Shanghai Sailing Program, National Natural Science Foundation of China (Grant No. 31600802), Key Project of the Shanghai Science and Technology Committee (18DZ1112703) and the Fundamental Research Funds for the Central Universities. We also appreciated the comments from Dr Jiliang Liu from Brookhaven National Lab of United States.

语种：英文

外文关键词：Controlled drug delivery - Oligonucleotides - Biocompatibility - Self assembly

摘要：A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.