文献类型：期刊文献

英文题名：An innovative and rapid method for permanent hydrophilic modification of polydimethylsiloxane (PDMS) chip surfaces

作者：Sheng, Shiqi[1];Wang, Minglei[2];Mu, Liuhua[3,4]

机构：[1]East China Univ Sci & Technol, Sch Phys, Shanghai 200237, Peoples R China;[2]Swiss Fed Inst Technol, Inst Environm Engn, CH-8093 Zurich, Switzerland;[3]Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Zhejiang, Peoples R China;[4]Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China

年份：2025

卷号：137

期号：1

外文期刊名：JOURNAL OF APPLIED PHYSICS

收录：;EI(收录号：20250417730913);WOS:【SCI-EXPANDED(收录号:WOS:001390828300015)】；

基金：We acknowledge the support from the Sino-Swiss Science and Cooperation Technology Programme 2021, the National Natural Science Foundation of China (NSFC) (Nos. 12305408, 12005062, and 12405036), and the Postdoctoral Fellowship Program of CPSF under Grant Nos. GZC20232610.

语种：英文

外文关键词：Fluidic logic devices - Grafting (chemical) - Plasma applications - Wetting

摘要：Polydimethylsiloxane (PDMS), a fundamental material in the fabrication of microfluidic devices, suffers from nonspecific adsorption of biological samples due to its hydrophobic nature. Herein, by employing a radiation-induced grafting strategy to introduce hydrophilic functional groups onto the PDMS surface, a significant improvement in hydrophilicity is achieved, leading to a notable reduction in the contact angle by up to similar to 90 degrees and improvement of antifouling performance against biological samples. Effects between monomer concentration, grafting efficiency, and mechanical integrity are balanced to optimize the grafting process, achieving promised hydrophilicity enhancement while the mechanical properties are not degraded. The content of carboxyl groups exposed on the surface of grafted PDMS was computationally analyzed using MD simulations, which revealed the key role of carboxyl groups in the wettability of the PDMS surface. Our study extensively showcases the effective grafting of acrylic acid onto PDMS, which is characterized by diverse grafting rates. Remarkably, the hydrophilic modification is stable over time compared to conventional plasma treatment, offering a more reliable and enduring strategy, and making it a valuable enhancement for PDMS chips with extensive applications.