文献类型：期刊文献

英文题名：Naphthalimide hydroperoxides as photonucleases: substituent effects and structural basis

作者：Tao, Zhi-Fu[1]; Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Inst Pesticides & Pharmaceut, Shanghai 200237, Peoples R China

年份：1999

卷号：43

期号：2

起止页码：139

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：1999494857444);WOS:【SCI-EXPANDED(收录号:WOS:000081949500009)】；

语种：英文

外文关键词：DNA cleaver; DNA intercalator; naphthalimide; peroxides; X-ray single crystal structure; hydroxyl radicals

摘要：A variety of naphthalimide hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on the substituents on the aromatic moiety. The DNA-cleaving differences of these hydroperoxides may result from the differences of the intercalating ability of the naphthalene moiety. X-ray single crystal structure of a representative compound 1 was determined, and showed that all endocyclic atoms were coplanar, indicating a structural basis for potential and efficient DNA intercalation by 1. (C) 1999 Elsevier Science Ltd. All rights reserved.