文献类型：期刊文献

英文题名：A Supramolecular-Based Dual-Wavelength Phototherapeutic Agent with Broad-Spectrum Antimicrobial Activity Against Drug-Resistant Bacteria

作者：Yu, Zhi-Hao[1,2];Li, Xingshu[4];Xu, Fugui[3];Hu, Xi-Le[1,2];Yan, Jiatao[5];Kwon, Nahyun[4];Chen, Guo-Rong[1,2];Tang, Tingting[6];Dong, Xiaojing[7];Mai, Yiyong[3];Chen, Daijie[7,8];Yoon, Juyoung[4];He, Xiao-Peng[1,2];Tian, He[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, 130 Meilong RD, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong RD, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai Key Lab Elect Insulat & Thermal Ageing, 800 Dongchuan RD, Shanghai 200240, Peoples R China;[4]Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea;[5]Shanghai Univ, Coll Mat Sci & Engn, Dept Polymer Mat, Shanghai 200444, Peoples R China;[6]Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Orthoped Implants, Dept Orthoped Surg,Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China;[7]Shanghai Inst Pharmaceut Ind, 285 Gebaini RD, Shanghai 201203, Peoples R China;[8]Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan RD, Shanghai 200240, Peoples R China

年份：2020

卷号：59

期号：9

起止页码：3658

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20200508111776);WOS:【SCI-EXPANDED(收录号:WOS:000508734700001)】；

基金：The authors thank Prof. Xinliang Feng at Technische Universit~t Dresden for help with some measurements. A. C. Sedgwick at UT Austin is appreciated for help in editing this manuscript. Financial support from the Natural Science Foundation of China (21788102, 91853201, 21774076, 51573091, 21722801 and 21776078), the National Research Foundation of Korea (NRF), which was funded by the Korea government (MSIP) (2012R1A3A2048814), the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the Program of Shanghai Academic Research Leader (19XD1421700), and the Program of Shanghai Eastern Scholar are gratefully acknowledged. The Instrumental Analysis Center of Shanghai Jiao Tong University is also acknowledged for some measurements.

语种：英文

外文关键词：antimicrobial activity; graphene nanoribbons; phototherapy; porphyrin; supramolecular structures

摘要：With the ever-increasing threat posed by the multi-drug resistance of bacteria, the development of non-antibiotic agents for the broad-spectrum eradication of clinically prevalent superbugs remains a global challenge. Here, we demonstrate the simple supramolecular self-assembly of structurally defined graphene nanoribbons (GNRs) with a cationic porphyrin (Pp4N) to afford unique one-dimensional wire-like GNR superstructures coated with Pp4N nanoparticles. This Pp4N/GNR nanocomposite displays excellent dual-modal properties with significant reactive-oxygen-species (ROS) production (in photodynamic therapy) and temperature elevation (in photothermal therapy) upon light irradiation at 660 and 808 nm, respectively. This combined approach proved synergistic, providing an impressive antimicrobial effect that led to the complete annihilation of a wide spectrum of Gram-positive, Gram-negative, and drug-resistant bacteria both in vitro and in vivo. The study also unveils the promise of GNRs as a new platform to develop dual-modal antimicrobial agents that are able to overcome antibiotic resistance.