文献类型：期刊文献

中文题名：育龄期妇女血清EFAs和NEFAs轮廓谱及其用于NTDs预防性营养干预研究

英文题名：Serum EFAs and NEFAs Metabolic Profiling Analysis Child-bearing Age Women and Its Application to NTDs Preventive Nutrition Intervention

作者：韩莉妲[1,2];梁琼麟[2];王义明[2];罗国安[1,2]

机构：[1]华东理工大学药学院,上海200237;[2]清华大学分析中心,北京100084

年份：2010

卷号：31

期号：1

起止页码：46

中文期刊名：高等学校化学学报

外文期刊名：Chemical Journal of Chinese Universities

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000274167500010)】；北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家"九七三"计划项目(批准号:2007CB511903)资助

语种：中文

中文关键词：营养干预;神经管畸形;脂肪酸;营养代谢组学;生物标志物

外文关键词：Nutrition intervention; Neural tube defects （NTDs）; Fatty acid; Nutrition metabonomics; Biomarker

摘要：本文借助GC/MS代谢组学方法,测定了育龄期妇女血清中酯化和非酯化脂肪酸轮廓谱,并对营养干预前后育龄期妇女血清脂肪酸含量变化进行了研究.按营养干预组(48例)和对照组(48例)分组,测定了育龄期妇女血清中酯化脂肪酸(EFAs)和非酯化脂肪酸(NEFAs)的平均含量;利用SIMCA-P软件对定量结果进行PLS-DA分析,聚类结果良好.基于定量结果,指认了6种潜在营养生物标志物,并由此初步探讨了这些潜在生物标志物的生理意义以及营养素干预对育龄期妇女血清脂肪酸含量的影响,以及脂肪酸代谢变化可能对胚胎神经发育造成的影响.
Nutrition intervention（NI） is the common means for Neural tube defects（NTDs） prevention. The serum EFAs and NEFAs metabolic profiling of Child-bearing age women was studied by GC/MS method. The subjects were random divided into two groups： NI group（ n = 48 ） and control group（ n = 48 ）. The mean levels of EFAs and NEFAs were reported. PLS-DA using the SIMCA-P software package allowed the different group to be distinguished, which means NI has great effects on the metabolism of fatty acids. Based on the quantification results, six FAs （both EFAs and NEFAs） were recognized as potential biomarkers. And the relationship between NI and the FAs＇ concentration variation was discussed to illustrate the potential impacts on the incidence of NTD.