文献类型：期刊文献

英文题名：Polylactic acid microplastics induce higher biotoxicity of decabromodiphenyl ethane on earthworms (Eisenia fetida) compared to polyethylene and polypropylene microplastics

作者：Han, Yanna[1,2];Fu, Mengru[1,2];Wu, Jinhong[3];Zhou, Shanqi[1];Qiao, Zhihua[1];Peng, Cheng[1];Zhang, Wei[1,2];Liu, Fang[2];Ye, Chunmei[2];Yang, Jie[2]

机构：[1]East China Univ Sci & Technol, Sch Resource & Environm Engn, State Environm Protect Key Lab Environm Risk Asses, Shanghai 200237, Peoples R China;[2]Shanghai Acad Environm Sci, State Environm Protect Engn Ctr Urban Soil Contami, Shanghai 200233, Peoples R China;[3]Shanghai Yaxin Urban Construction Co Ltd, Shanghai 200436, Peoples R China

年份：2023

卷号：862

外文期刊名：SCIENCE OF THE TOTAL ENVIRONMENT

收录：;EI(收录号：20225113270982);WOS:【SCI-EXPANDED(收录号:WOS:000901727600010)】；

基金：This paper was supported by the National Natural Science Foundation of China (41877124, 21737005, 42177395) , and the Special Fund of State Environmental Protection Engineering Center for Urban Soil Contamina-tion Control and Remediation (USCR-202206) .

语种：英文

外文关键词：Decabromodiphenyl ethane; Microplastics; Neurotoxicity; Histopathology; Transcriptome

摘要：Decabromodiphenyl ethane (DBDPE) and microplastics (MPs), such as fossil-based polymers polyethylene (PE), poly-propylene (PP), and bio-based plastics polylactic acid (PLA) are abundant in e-waste dismantling areas. However, the information on the effects of DBDPE combined with MPs (DBDPE-MPs) on earthworms is still limited. In this study, we explored the impacts of DBDPE-MPs on neurotoxic biomarkers, tissue damage, and transcriptomics of Eisenia fetida by simulating different exposure patterns of 10 mg kg-1 DBDPE and 10 mg kg-1 DBDPE-MPs (PLA, PP, and PE). Results showed that the activities of acetylcholinesterase, Na+/K+-ATPase, Ca2+/Mg2+-ATPase, carboxylate enzyme, and the contents of calcium and glutamate were significantly stimulated. DBDPE-MP co-exposure caused more severe dam-age to the epidermis, muscles, and tissues. Transcriptomic analysis revealed that differentially expressed genes (DEGs) of DBDPE-MPs were mainly related to inflammation, the immune system, digestive system, endocrine system, and me-tabolism. DBDPE and PP-MPs had similar influences on immunity and metabolism. However, DBDPE-PLA and DBDPE-PE further affected the endocrine system and signaling pathways. Specific DEGs showed that detoxification systems in the case of MPs were significantly upregulated. The study indicated that MPs exacerbated DBDPE toxicity in the ner-vous system, epidermis, and gene regulation of E. fetida, helping to assess the ecological risks of e-wastes and microplastics in soil.