文献类型：期刊文献

英文题名：Multifunctional Carbon Dots for Biomedical Applications: Diagnosis, Therapy, and Theranostic

作者：Wang, Jiayi[1,2];Fu, Yu[3];Gu, Zhanghao[1,2];Pan, Hao[1,2];Zhou, Panyu[4];Gan, Qi[1,2,5];Yuan, Yuan[1,2,5];Liu, Changsheng[1,2,5,6]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]Tongji Univ, Sch Aerosp Engn & Appl Mech, ZhangWu Rd 100, Shanghai 200092, Peoples R China;[4]Naval Med Univ, Changhai Hosp, Dept Orthoped, Shanghai 200433, Peoples R China;[5]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[6]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China

年份：2024

卷号：20

期号：3

外文期刊名：SMALL

收录：;EI(收录号：20233714722940);WOS:【SCI-EXPANDED(收录号:WOS:001064571500001)】；

基金：This work was supported by the National Natural Science Foundation of China (No. T2288102, 32071337), the National Key R&D Program of China (No. 2022YFB3804300), the Shanghai Pujiang Program (20PJ1402600), the 111 Project (B14018), and the NavalMedical University Science Youth Cultivation Program Incubation Project. This study was also supported by the "Fundamental Research Funds for the Central Universities".

语种：英文

外文关键词：carbon dots; diagnosis; therapy; theranostic

摘要：Designing suitable nanomaterials is an ideal strategy to enable early diagnosis and effective treatment of diseases. Carbon dots (CDs) are luminescent carbonaceous nanoparticles that have attracted considerable attention. Through facile synthesis, they process properties including tunable light emission, low toxicity, and light energy transformation, leading to diverse applications as optically functional materials in biomedical fields. Recently, their potentials have been further explored, such as enzyme-like activity and ability to promote osteogenic differentiation. Through refined synthesizing strategies carbon dots, a rich treasure trove for new discoveries, stand a chance to guide significant development in biomedical applications. In this review, the authors start with a brief introduction to CDs. By presenting mechanisms and examples, the authors focus on how they can be used in diagnosing and treating diseases, including bioimaging failure of tissues and cells, biosensing various pathogenic factors and biomarkers, tissue defect repair, anti-inflammation, antibacterial and antiviral, and novel oncology treatment. The introduction of the application of integrated diagnosis and treatment follows closely behind. Furthermore, the challenges and future directions of CDs are discussed. The authors hope this review will provide critical perspectives to inspire new discoveries on CDs and prompt their advances in biomedical applications. Carbon dots (CDs) possess various properties and are a rich treasure trove for new discoveries. Through refined synthesizing strategies, CDs stand a chance to guide significant development in biomedical applications. Various biomedical applications are elaborated from three aspects: diagnosis, therapy, and theranostic. Challenges and future directions of CDs are also presented.image