文献类型：期刊文献

英文题名：Facile synthesis of multisubstituted buta-1,3-dienes via Suzuki-Miyaura and Kumada cross-coupling strategy of 2,4-diiodo-buta-1-enes with arylboronic acids and Grignard reagents

作者：Shao, Li-Xiong[1]; Shi, Min[2]

机构：[1] State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032, China; [2] East China University of Science and Technology, 130 Mei Long Lu, Shanghai, 200237, China

年份：2005

卷号：3

期号：10

起止页码：1828

外文期刊名：Organic and Biomolecular Chemistry

收录：EI(收录号：2005249155820)

语种：英文

外文关键词：Catalysts - Chemotherapy - Magnesium compounds - Medical problems - Neurology - Organic acids - Organic polymers - Tumors

摘要：One-pot Suzuki-Miyaura-type and Kumada-type cross-coupling reactions of 2,4-diiodo-buta-l-enes with arylboronic acids and alkyl/aryl magnesium bromides were carried out in the presence of accessibly simple catalysts under mild conditions. As a result, some 1,1,2-trisubstituted buta-1,3-dienes were obtained including the Tamoxifen-type, which have potential adjuvant therapy in women who have suffered from breast cancer and cyclooxygenase-2-type (COX-2-type) inhibitors, some of which have been proved to elicit efficient anti-inflammatory analgesic activities and less adverse gastrointestinal side effects and to be very useful in the prophylactic treatment of a wide variety of cancers and neurodegenerative disorders. ? The Royal Society of Chemistry 2005.