文献类型：期刊文献

英文题名：Immunosuppressive Polyketides from Mantis-Associated Daldinia eschscholzii

作者：Zhang, Ying L.[1,4];Zhang, Jie[1];Jiang, Nan[2];Lu, Yan H.[3];Wang, Lu[1];Xu, Su H.[1];Wang, Wei[1];Zhang, Gao F.[1];Xu, Qiang[1];Ge, Hui M.[1];Ma, Jing[2];Song, Yong C.[1];Tan, Ren X.[1]

机构：[1]Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China;[2]Nanjing Univ, Inst Theoret & Computat Chem, Lab Mesoscop Chem, Nanjing 210093, Peoples R China;[3]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Zhejiang Normal Univ, Coll Chem & Life Sci, Jinhua 321004, Peoples R China

年份：2011

卷号：133

期号：15

起止页码：5931

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000290358200065)】；

基金：Co-acknowledged are the financial supports from MOST (2009ZX09501-013), and NSFC (21072092, 90813036, and 30821006). We also appreciate the fruitful discussions with Prof. D. W. Ma at Shanghai Inst. Org. Chem., Chinese Acad. Sci., P. R. China.

语种：英文

摘要：Polyketides with unknown architectures are highly desired for the discovery of new drugs and agrochemicals. Here, the mantis-associated Daldinia eschscholzii, a fungus known to produce immunosuppressants dalesconols A and B, was found to simultaneously generate four novel skeletons capable of shaping the unusual chemistry of the fungal polyketides, of which seven were structurally unique and substantially immunosuppressive. In particular, the scaled-up fermentation of the microbe enabled the structural characterization of minor or "transitional" intermediate polyketides that allowed the reasonable recognition of the four biosynthetic pathways initiated by condensations of four, five, six and eight acetate units, respectively. Furthermore, the decarbonylation reaction of triketone, as in the case of daeschol A, was described for the first time, in addition to the structural correction of sporothrin C and nodulone. The work provided a set of novel immunosuppressive molecules that are of significance to drug discovery.